Supplemental Material 3

Graph Metrics and NFS-BI

Power Atlas

After adjusting for age, scanning site, Other TBI, and IPV-HT frequency, near-fatal strangulation-related brain injury (NFS-BI) was only significantly associated with modularity, within default mode network strength, and default mode network segregation. The reference category for scanning site was Scanning Site 1 and the reference category for IPV-HT frequency was 1-4.

eTable 1: Density

Seitzman Atlas - Linear Model Summary (Density ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.301	0.010	29.574	0.000
NFS-BI	-0.001	0.004	-0.414	0.680
Other TBI	0.004	0.004	1.031	0.305
Site 2	-0.018	0.006	-2.783	0.006
Site 3	-0.009	0.007	-1.375	0.172
Site 4	-0.013	0.006	-2.095	0.039
IPV-HT: 5-9	-0.005	0.005	-0.923	0.358
IPV-HT: 10+	-0.001	0.004	-0.333	0.740
Age	0.000	0.000	-0.271	0.787

eTable 2: Modularity

Power Atlas - Linear Model Summary (Modularity ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.182	0.014	12.567	0.000
NFS-BI	-0.012	0.005	-2.466	0.015
Other TBI	0.002	0.006	0.259	0.796
Site 2	-0.008	0.009	-0.874	0.384
Site 3	0.004	0.010	0.466	0.642
Site 4	-0.008	0.009	-0.842	0.402
IPV-HT: 5-9	0.014	0.007	1.942	0.055
IPV-HT: 10+	0.007	0.006	1.151	0.253
Age	-0.001	0.000	-4.165	0.000

eTable 3: Efficiency

Power Atlas - Linear Model Summary (Efficiency ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.224	0.008	27.652	0.000
NFS-BI	-0.004	0.003	-1.570	0.120
Other TBI	0.004	0.003	1.248	0.215
Site 2	-0.014	0.005	-2.837	0.006
Site 3	-0.007	0.005	-1.248	0.215
Site 4	-0.014	0.005	-2.665	0.009
IPV-HT: 5-9	0.001	0.004	0.172	0.864
IPV-HT: 10+	0.003	0.003	0.837	0.404
Age	0.000	0.000	-3.231	0.002

eTable 4: Path Length

Power Atlas - Linear Model Summary (Path Length ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	5.220	0.203	25.677	0.000
NFS-BI	0.079	0.071	1.110	0.270
Other TBI	-0.086	0.085	-1.010	0.315
Site 2	0.292	0.126	2.312	0.023
Site 3	0.127	0.135	0.936	0.351
Site 4	0.258	0.128	2.017	0.046
IPV-HT: 5-9	-0.011	0.098	-0.112	0.911
IPV-HT: 10+	-0.042	0.082	-0.507	0.613
Age	0.009	0.003	2.958	0.004

eTable 5: DMN - Within Network Strength

Power Atlas - Linear Model Summary (DMN-Within ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.341	0.027	12.458	0.000
NFS-BI	-0.033	0.010	-3.432	0.001
Other TBI	0.027	0.011	2.385	0.019
Site 2	-0.023	0.017	-1.354	0.179
Site 3	-0.006	0.018	-0.348	0.728
Site 4	-0.024	0.017	-1.402	0.164
IPV-HT: 5-9	0.013	0.013	1.001	0.319
IPV-HT: 10+	0.016	0.011	1.429	0.156
Age	-0.001	0.000	-3.400	0.001

eTable 6: DMN - Between Network Strength

Power Atlas - Linear Model Summary (DMN-Between Newtork Strength ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.177	0.008	20.872	0.000
NFS-BI	-0.004	0.003	-1.374	0.172
Other TBI	0.004	0.004	1.185	0.239
Site 2	-0.014	0.005	-2.725	0.008
Site 3	-0.008	0.006	-1.489	0.140
Site 4	-0.014	0.005	-2.593	0.011
IPV-HT: 5-9	-0.003	0.004	-0.694	0.489
IPV-HT: 10+	0.003	0.003	0.955	0.342
Age	0.000	0.000	-2.707	0.008

eTable 7: DMN - Segregation

Power Atlas - Linear Model Summary (DMN-Segregation ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.486	0.044	11.089	0.000
NFS-BI	-0.046	0.015	-3.033	0.003
Other TBI	0.034	0.018	1.881	0.063
Site 2	0.000	0.027	-0.017	0.986
Site 3	0.015	0.029	0.525	0.601
Site 4	-0.004	0.028	-0.150	0.881
IPV-HT: 5-9	0.039	0.021	1.830	0.070
IPV-HT: 10+	0.023	0.018	1.326	0.188
Age	-0.002	0.001	-2.451	0.016

eFigure 1: Average within default mode network connectivity of each NFS-BI group and differences between groups

Within DMN strength plots for Power Atlas. Only the connections that were in the top 10% of difference between the No NFS-BI group and the Yes NFS-BI group are plotted.

Seitzman Atlas

After adjusting for age, scanning site, Other TBI, and IPV-HT frequency, near-fatal strangulation-related brain injury (NFS-BI) was only significantly associated with modularity, within default mode network strength, and default mode network segregation. The reference category for scanning site was Scanning Site 1 and the reference category for IPV-HT frequency was 1-4.

eTable 8: Density

Seitzman Atlas - Linear Model Summary (Density ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.299	0.009	32.325	0.000
NFS-BI	-0.001	0.003	-0.375	0.708
Other TBI	0.002	0.004	0.520	0.604
Site 2	-0.016	0.006	-2.815	0.006
Site 3	-0.008	0.006	-1.371	0.173
Site 4	-0.013	0.006	-2.238	0.027
IPV-HT: 5-9	-0.005	0.004	-1.091	0.278
IPV-HT: 10+	0.000	0.004	0.064	0.949
Age	0.000	0.000	-0.258	0.797

eTable 9: Modularity

Seitzman Atlas - Linear Model Summary (Modularity ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.173	0.015	11.313	0.000
NFS-BI	-0.015	0.005	-2.866	0.005
Other TBI	0.005	0.006	0.758	0.450
Site 2	-0.009	0.010	-0.971	0.334
Site 3	0.008	0.010	0.772	0.442
Site 4	-0.007	0.010	-0.719	0.474
IPV-HT: 5-9	0.016	0.007	2.154	0.034
IPV-HT: 10+	0.009	0.006	1.405	0.163
Age	-0.001	0.000	-4.366	0.000

eTable 10: Efficiency

Seitzman Atlas - Linear Model Summary (Efficiency ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.209	0.007	28.843	0.000
NFS-BI	-0.003	0.003	-1.378	0.171
Other TBI	0.003	0.003	1.077	0.284
Site 2	-0.013	0.005	-2.814	0.006
Site 3	-0.006	0.005	-1.316	0.191
Site 4	-0.011	0.005	-2.492	0.014
IPV-HT: 5-9	0.001	0.004	0.170	0.866
IPV-HT: 10+	0.002	0.003	0.750	0.455
Age	0.000	0.000	-2.649	0.009

eTable 11: Path Length

Seitzman Atlas - Linear Model Summary (Path Length ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	5.524	0.197	28.059	0.000
NFS-BI	0.061	0.069	0.885	0.378
Other TBI	-0.069	0.082	-0.845	0.400
Site 2	0.281	0.122	2.302	0.023
Site 3	0.143	0.131	1.090	0.278
Site 4	0.235	0.124	1.901	0.060
IPV-HT: 5-9	-0.014	0.095	-0.144	0.886
IPV-HT: 10+	-0.038	0.079	-0.477	0.634
Age	0.007	0.003	2.323	0.022

eTable 12: DMN - Within Network Strength

Seitzman Atlas - Linear Model Summary (DMN-Within ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.296	0.024	12.581	0.000
NFS-BI	-0.026	0.008	-3.224	0.002
Other TBI	0.021	0.010	2.152	0.034
Site 2	-0.017	0.015	-1.195	0.235
Site 3	0.002	0.016	0.106	0.916
Site 4	-0.016	0.015	-1.114	0.268
IPV-HT: 5-9	0.010	0.011	0.835	0.405
IPV-HT: 10+	0.013	0.009	1.351	0.180
Age	-0.001	0.000	-2.906	0.004

eTable 13: DMN - Between Network Strength

Seitzman Atlas - Linear Model Summary (DMN-Between Newtork Strength ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.159	0.007	21.279	0.000
NFS-BI	-0.002	0.003	-0.865	0.389
Other TBI	0.002	0.003	0.780	0.437
Site 2	-0.011	0.005	-2.476	0.015
Site 3	-0.008	0.005	-1.518	0.132
Site 4	-0.011	0.005	-2.282	0.025
IPV-HT: 5-9	-0.004	0.004	-1.213	0.228
IPV-HT: 10+	0.002	0.003	0.531	0.597
Age	0.000	0.000	-1.555	0.123

eTable 14: DMN - Segregation

Seitzman Atlas - Linear Model Summary (DMN-Segregation ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.470	0.045	10.503	0.000
NFS-BI	-0.046	0.016	-2.918	0.004
Other TBI	0.034	0.019	1.806	0.074
Site 2	0.004	0.028	0.155	0.877
Site 3	0.034	0.030	1.145	0.255
Site 4	0.002	0.028	0.067	0.947
IPV-HT: 5-9	0.037	0.022	1.692	0.094
IPV-HT: 10+	0.022	0.018	1.199	0.233
Age	-0.002	0.001	-2.697	0.008

eFigure 2: Average within default mode network connectivity of each NFS-BI group and differences between groups

Within DMN strength plots for Seitzman Atlas. Only the connections that were in the top 10% of difference between the No NFS-BI group and the Yes NFS-BI group are plotted.

4S Atlas

After adjusting for age, scanning site, Other TBI, and IPV-HT frequency, near-fatal strangulation-related brain injury (NFS-BI) was only significantly associated with modularity, within default mode network strength, and default mode network segregation. The reference category for scanning site was Scanning Site 1 and the reference category for IPV-HT frequency was 1-4.

eTable 15: Density

4S Atlas - Linear Model Summary (Density ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.329	0.010	32.103	0.000
NFS-BI	-0.001	0.004	-0.378	0.706
Other TBI	0.006	0.004	1.466	0.146
Site 2	-0.015	0.006	-2.430	0.017
Site 3	-0.010	0.007	-1.503	0.136
Site 4	-0.012	0.006	-1.928	0.057
IPV-HT: 5-9	-0.005	0.005	-1.070	0.287
IPV-HT: 10+	-0.001	0.004	-0.314	0.754
Age	0.000	0.000	1.375	0.172

eTable 16: Modularity

4S Atlas - Linear Model Summary (Modularity ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.249	0.016	15.501	0.000
NFS-BI	-0.015	0.006	-2.675	0.009
Other TBI	-0.001	0.007	-0.110	0.913
Site 2	0.000	0.010	0.025	0.980
Site 3	0.005	0.011	0.489	0.626
Site 4	-0.004	0.010	-0.356	0.723
IPV-HT: 5-9	0.014	0.008	1.845	0.068
IPV-HT: 10+	0.009	0.006	1.361	0.177
Age	-0.001	0.000	-4.245	0.000

eTable 17: Efficiency

4S Atlas - Linear Model Summary (Efficiency ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.268	0.009	31.039	0.000
NFS-BI	-0.005	0.003	-1.703	0.092
Other TBI	0.006	0.004	1.605	0.112
Site 2	-0.015	0.005	-2.866	0.005
Site 3	-0.009	0.006	-1.486	0.140
Site 4	-0.016	0.005	-2.936	0.004
IPV-HT: 5-9	0.000	0.004	0.066	0.947
IPV-HT: 10+	0.002	0.003	0.616	0.539
Age	0.000	0.000	-2.433	0.017

eTable 18: Path Length

4S Atlas - Linear Model Summary (Path Length ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	4.424	0.136	32.595	0.000
NFS-BI	0.049	0.047	1.028	0.307
Other TBI	-0.079	0.057	-1.391	0.167
Site 2	0.216	0.084	2.560	0.012
Site 3	0.130	0.090	1.443	0.152
Site 4	0.212	0.085	2.488	0.015
IPV-HT: 5-9	-0.010	0.066	-0.147	0.884
IPV-HT: 10+	-0.016	0.055	-0.293	0.770
Age	0.005	0.002	2.264	0.026

eTable 19: DMN - Within Network Strength

4S Atlas - Linear Model Summary (DMN-Within ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.428	0.031	13.700	0.000
NFS-BI	-0.028	0.011	-2.542	0.013
Other TBI	0.015	0.013	1.149	0.253
Site 2	-0.021	0.019	-1.083	0.281
Site 3	0.001	0.021	0.037	0.971
Site 4	-0.022	0.020	-1.110	0.270
IPV-HT: 5-9	0.002	0.015	0.107	0.915
IPV-HT: 10+	0.014	0.013	1.101	0.273
Age	-0.001	0.000	-2.930	0.004

eTable 20: DMN - Between Network Strength

4S Atlas - Linear Model Summary (DMN-Between Newtork Strength ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.204	0.009	21.798	0.000
NFS-BI	-0.001	0.003	-0.442	0.659
Other TBI	0.003	0.004	0.695	0.489
Site 2	-0.019	0.006	-3.275	0.001
Site 3	-0.013	0.006	-2.160	0.033
Site 4	-0.020	0.006	-3.384	0.001
IPV-HT: 5-9	-0.004	0.005	-0.837	0.405
IPV-HT: 10+	0.001	0.004	0.249	0.804
Age	0.000	0.000	-1.141	0.257

eTable 21: DMN - Segregation

4S Atlas - Linear Model Summary (DMN-Segregation ~ NFS-BI + Other TBI + IPV-HT Frequency + Site + Age)

Variable	Coefficient	SE	Statistic	P_Value
(Intercept)	0.532	0.034	15.643	0.000
NFS-BI	-0.030	0.012	-2.504	0.014
Other TBI	0.008	0.014	0.547	0.586
Site 2	0.023	0.021	1.080	0.283
Site 3	0.041	0.023	1.794	0.076
Site 4	0.022	0.021	1.053	0.295
IPV-HT: 5-9	0.012	0.016	0.725	0.470
IPV-HT: 10+	0.018	0.014	1.348	0.181
Age	-0.002	0.001	-3.297	0.001

eFigure 3: Average within default mode network connectivity of each NFS-BI group and differences between groups

Within DMN strength plots for 4S Atlas. Only the connections that were in the top 10% of difference between the No NFS-BI group and the Yes NFS-BI group are plotted.